Toxicity of Olea africana in Artemia Salina and Mice

The current study investigated the toxicity of ethanol extract _Olea africana_ in mice and brine shrimp _(Artemia salina)_. Brine cytotoxicity acute were observed over 24 hours. Subacute was studied for 28 days using animal weight, organ-to-body weight ratio, hematological, biochemical histological parameters as indicators. Data analysis done Probit regression Two Way ANOVA _(p<0.05)_. lethal concentration responsible 50% mortality (LC50) 2257.84 µg/mL (702.97-7367.95), while dose (LD50) 4297.30 mg/kg. There no significant differences mean or ratio control treatment group mice. Some hematological extract-treated significantly different from Adverse histopathological changes including fibrosis around hepatic artery, degeneration hepatocytes, congestion, mild portal vein artery livers Perivascular infiltration, fibrosis, glomerular degeneration, tubular cell hemorrhage kidneys Given these findings, prolonged administration is associated with toxic concern. As a result, caution should be exercised when extract.